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Morpheus search algorithm

a mass spectrometry–based proteomics database search algorithm

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Description

Morpheus is a mass spectrometry–based proteomics database search algorithm designed from the ground up for high-resolution tandem mass spectra. We have discovered that for high-resolution MS/MS, simple spectrum preprocessing and scoring performs superior to more complex algorithms originally developed for low-resolution MS/MS, such as Sequest, Mascot, and OMSSA. Morpheus is also very fast—up to nearly 5 times faster than OMSSA for large human datasets. It is written in C# and is available open source under the permissive MIT License.

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Categories

Bio-Informatics, Chemistry

License

MIT License

Features

  • Support for mzML, Thermo .raw, or Agilent .d data
  • Multi-threaded
  • Automatic spectrum-, peptide-, and protein-level FDR
  • Tab-delimited and pepXML outputs

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Additional Project Details

Intended Audience

Science/Research

User Interface

.NET/Mono, Command-line, Win32 (MS Windows)

Programming Language

C#

Registered

2013-05-06
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