Please refer to the original article published in PLOS ONE at http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049386.
GUItars's user-friendly graphical interface enables rapid analysis setup with the aid of specially designed pop-up menus, push buttons, and checkboxes. GUItars uses SSMD for hit selection, which is preferred for its ability to diminish sample size effects and the false hit rate, making it superior to other widely used HTS analysis methods. The program can handle the analysis for screens without replicates as well as with replicates. For comparison purposes, non-SSMD-based methods such as percent activity, z-score, and t-test are also provided as scoring options. Although GUItars is designed for the analysis of RNAi screening data, it is also applicable for small molecule screens.
Version 2.1 released: several bugs fixed
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