Goo Media Center

you could install GMC to the drive letter of the usb pen drive but the only problem would be the settings file that is saved to the root of c:.
so in theory you would get a "unable to load settings" each time you fired up the program.

probably the best idea is to have the installer on usb pen drive and just install on each pc.

this way you will know that GMC will work.

I do have another piece of software (hosted on sourceforge) called movieplayer and this is a live program that runs from wherever it is installed (like a cd for example).

check it out here :-

http://sourceforge.net/projects/movieplayer/

hope it helps.