EMBOSS is a dynamic and comprehensive Open Source package for bioinformatics (DNA and protein sequence analysis, protein structure, phylogenetics, etc.). EMBOSS is written in C, also compatible with C++, and has a separate Java interface (Jemboss)
Working on 454 run with long linkers and random insert orientation, only EMBOSS could help me to produce a clean FASTQ file with orientation corrected and linkers removed.
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