A Deformable Medical Image Registration Toolbox

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DRAMMS is a software package designed for 2D-to-2D and 3D-to-3D deformable medical image registration tasks. Released by Section of Biomedical Image Analysis (SBIA) at the University of Pennsylvania.

Some typical applications of DRAMMS include,

-- Cross-subject registration of the same organ (can be brain, breast, cardiac, etc);

-- Mono- and Multi-modality registration (MRI, CT, histology);

-- Longitudinal registration (pediatric brain growth, cancer development, mouse brain development, etc);

-- Registration under missing correspondences (e.g., vascular lesions, tumors, histological cuts).

DRAMMS runs in command line in UNIX/Mac OS, It accepts Nifti/ANALYZE/MetaImage image formats. It is fully-automatic --- takes two input images, and generates a registered image and (optionally) the deformation field.

More information (installation, tutorial, manual, demonstration, FAQ, etc) can be found at http://www.rad.upenn.edu/sbia/software/dramms/ .



  • Fully-automatic --- no need for segmentation or any prior knowledge or user-initialization/intervention
  • User-friendly --- two input images, two output (the registered image and the deformaiton field)
  • Generality --- default parameters work reasonably well for most cases (raw images, preprocessed images, multi-site data, etc)


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Additional Project Details

Intended Audience

End Users/Desktop, Engineering, Healthcare Industry, Science/Research

User Interface

Command-line, Console/Terminal

Programming Language

C++, Unix Shell


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