When starting up WineskinX11 then launching a few titles like Oblivion, the OSX and X mouse to not sync to the same spot in the screen causing the mouse to not be moveable everywhere.
Older Wine versions do not have this problem until the xinput2 mouse changes.
This same problem happens at times in XQuartz at times when XQuartz isn't already running. Launching XQuartz first usually fixes it. Need to figure out why its happening on WineskinX11 and/or a work a round.