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Upon opening VMPK for the first time, I found working the virtual keyboard with my mouse and alphanumeric keyboard worked well. Then, upon enabling MIDI input and selecting the appropriate device from the drop-down menu, I found that my MIDI keyboard would highlight keys but produce no sound. The mouse and alphanumeric keyboard would still work. I restarted VMPK, but then it would not even let me enable MIDI input. I re-installed and got the same results. I can remember getting it to work before, however.
First of all: which operating system are you using? this information is fundamental, because without it I can't propose any diagnostic procedure for your MIDI system. Second: do you realize that VMPK doesn't produce any sound by itself, only MIDI events?. If you can hear sound from your computer when you hit some keys, that means a MIDI Synthesizer is connected to VMPK's output port. Which synthesizer are you using?
A) Edit, Connections: 1) Enable MIDI input, 2) Enable MIDI Thru, 3) Input MIDI Connection: Edirol UM-1 MIDI (mine), 4) Output MIDI Connection: Microsoft GS Wavetable Synth (now have link for freeware synths that are much bigger and better)
B) Canal: set to 8 (to see pressed keys on midi keyboard)