Sorry if I'm offending somebody's artistic sensibility, but the Twitux icon is awful. I have no idea what it's supposed to represent, and it stands out way too much in the notification area. When something is red, I assume it requires my immediate attention. Nothing on Twitter will ever be that important ;)
On both of my systems with Twitux installed, I have replaced the icon to something milder (attached, as a suggestion). It's just a blue t (I doubt there's much of a trademark issue).
It would be very nice if there were an easier way to swap out the icons (although I guess that's more of a feature request for Gnome), or perhaps Twitux could just switch... anyway, just my $0.02.