Name: cis-regulatory module
SO accession: SO:0000727
def: A regulatory region where transcription factor binding sites clustered to regulate various aspects of transcription activities. "CRMs can be located a few kb to hundred kb upstream of the basal promoter, in the coding sequence, within introns, or in the downstream 3'UTR sequences, as well as on different chromosome...". A single gene can be regulated by multiple CRMs to give precise control of its spatial and temporal expression. CRMs function as nodes in large, intertwined regulatory network.
synonyms: CRM, cis regulatory module, TF module, transcription factor module
children: silencer, locus control region, enhancer, promoters, insulators