One of the big problems I have is that I read the same set of feeds at home and at work. I could use a web-based reader, but I haven't found one I like.
Is it possible to synchronize an OPML file in two installations of RSSOwl, so that I can see the same view, with the same read/unread posts, in both places?
Not yet, sorry. You could synchronize your feeds using a "Synchronized Blogroll", but thats not including the state of read news.
I need this feature too.