Specifically I'd like to see if it were possible to add support for the Universal Image Format (.UIF).
From a storage standpoint, Legend of Legaia:
455,774 KB ISO/BIN
278,025 KB UIF
I know so far the P.E.Op.S CDR plugin only addresses physical drives. There are no plugins which support UIF and ePSXeCutor does a good job of iso/bin/img. Other than UIF being compressed it also offers security (built-in MD5 checksum & password).