I'm a new user, and had quite a bit of trouble with Password Safe. To start, the help entry in the "Help" tab didn't work. It is now, don't know why, though I did open the help file in the C:... directory by hand. It didn't on a clean install.
It's really confusing that it runs all the time, showing up in the taskbar. I thought I'd exited, then restarted, and was confused when I tried to reopen my database because something else already had it open.
For what it's worth, hope these comments help...
Another nit: using shift-click to select multiple items doesn't work (when moving a group of passwords to a different group for example).