The Human Proteome Organization Standards Initiative has a proposed a community guideline regarding how to fully describe a molecular interaction experiment, called MIMIx, and an interchange standard for describing such experiments, PSI-MI (currently in version 2.5.3). This work was originally described in Hermjakob, et al. (2004) The HUPO PSI's molecular interaction format—a community standard for the representation of protein interaction data Nat. Biotechnol, . 22, 177–183 and the 2.5 release is described in Kerrien et al., Broadening the horizon-level 2.5 of the HUPO-PSI format for molecular interactions, BMC Biol. 5 (2007), p. 44. This standard is used by a variety of important public resources, including MINT, IntAct, DOMINO, CORUM and as the basis for an aspect of the BioCreative II text mining competition.
Recently, the Structured Digital Abstract initiative at FEBS letters (see Ceol, et al., Linking entries in protein interaction database to structured text: The FEBS Letters experiment, FEBS Letters Volume 582, Issue 8, 9 April 2008, Pages 1171-1177 adopted the PSI-MI as its source of relationships between proteins, as well as for describing the evidence for each assertion.
In the interests of ensuring compatibility between the RO and these important community resources, the relationships from the PSI-MI ontology need to be assessed for inclusion in the RO.
There are relevant portions of the PSI-MI are the molecular interactions (MI:0190 and children) and possibly the interaction detection method (MI:0001 and children), participant identification method (MI:0002 and children) and feature detection method (MI:0003) as kinds of supports relations.