#725 placenta labyrinth

closed-rejected
Cynthia Smith
None
5
2010-07-14
2010-07-14
Cynthia Smith
No

The labyrinth in mouse is derived from the trophectoderm of the early embryo and is part of the extraembryonic tissues. It's not derived from maternal tissues. The labyrinth does have a cavity into which maternally-derived blood from the spiral arteries flows through trophoblast-lined “canals” that carry maternal blood to the base of the placenta for exchange with fetal blood.

http://www3.interscience.wiley.com.ezproxy.jax.org/cgi-bin/fulltext/118552334/HTMLSTART

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDG-46X8T85-B&_user=584359&_coverDate=10%2F15%2F2002&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000029819&_version=1&_urlVersion=0&_userid=584359&md5=8bf23fb5b5dba5c6c858383ae3c643f8

Human placentas are structurally different.

Howard Dene wrote:
> Hi Cindy,
>
> I am sending this as an e-mail because I am not proposing any MP terms
> or MP re-arrangement at the moment.
> The placenta is a complex structure with both maternal and embryonic
> components. Currently terms related to the placenta are found only
> under embryogenesis. I would be inclined to argue however, that
> maternal structures such as the labyrinth could be considered part of
> the reproductive phenotype of the mother rather than an embryogenesis
> phenotype of the embryo. Certainly the maternal placenta can be
> expected to influence phenotypes such as litter size, gestation length,
> spontaneous abortion rate, and other similar phenotypes that we do
> consider maternal phenotypes. Just a thought -- I am annotating a
> paper on Il10 knockouts where the phenotype is cross-sectional area of
> the placental labyrinth. The important genotype (I think) is that of
> the mother, not the embryo but I will be annotating to embryogenesis terms.
>
> Howard
>
>

Discussion

  • Cynthia Smith
    Cynthia Smith
    2010-07-14

    See also PMID:11433360

     
  • Cynthia Smith
    Cynthia Smith
    2010-07-14

    • status: open --> closed-rejected