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#1687 enteric/vagal/sacral neural crest cell migration

None
closed-accepted
Cynthia Smith
5
2014-05-06
2014-03-11
No

Please add the following as a children terms of "abnormal neural crest cell migration [MP:0002950]"

abnormal enteric neural crest cell migration
DEF: any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)
SYN: abnormal enteric neural crest-derived cell migration
SYN: abnormal ENCC migration
SYN: abnormal ENCDC migration
From J:30830, J:108439, J:116089, J:119015, J:134482, J:140320, J:159854, J:135153

DEFINITION SOURCES:

(1) Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production. Dev Biol. 2013 Oct 15;382(2):446-56. doi: 10.1016/j.ydbio.2013.08.006. PMID: 23958436
(2) Enteric nervous system development and Hirschsprung’s disease: advances in genetic and stem cell studies. Nature Reviews Neuroscience 8, 466-479 (June 2007) doi:10.1038/nrn2137
(3) J:175558
NOTE from J:175558 abstract: In organotypic culture, genetically labeled sacral and vagal NCCs displayed different capabilities of entering the hindgut, implying differences in their intrinsic migratory properties. Time-lapse live-cell imaging on explants ex vivo showed that sacral NCCs migrated along nerve fibers and exhibited different migratory behaviors from vagal NCCs.


abnormal vagal neural crest cell migration
DEF: any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7; at approximately E8.5-9 in the mouse, vagal NCCs invade the anterior foregut and migrate in a rostral to caudal direction to colonize the entire foregut, midgut, cecum, and hindgut and give rise to the majority of the enteric nervous system (ENS); colonization is complete by E15.5 (or after 7 weeks gestation in humans); the most caudal vagal NCCs, emanating from a region overlapping with the most anterior trunk NCCs, make a small contribution to the ENS of the esophagus and the anterior stomach

DEFINITION SOURCES:

(1) Enteric nervous system development and Hirschsprung’s disease: advances in genetic and stem cell studies. Nature Reviews Neuroscience 8, 466-479 (June 2007) doi:10.1038/nrn2137


abnormal sacral neural crest cell migration
DEF: any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the sacral region of the neural tube (sacral neural crest), caudal to somite 28, and migrate caudo-rostrally to contribute to a small fraction of enteric neurons and glia in the distal midgut and hindgut; in the mouse, sacral NCCs emigrate from the neural tube at E9.5, accumulate bilateral to the hindgut to form prospective pelvic ganglia at E11.5, and from there enter the distal hindgut through its ventrolateral side at E13.5; they then migrate along nerve fibers extending from the pelvic ganglia toward the proximal hindgut, intermingling with rostrocaudally migrating vagal NCCs to differentiate into neurons and glia

DEFINITION SOURCES:

(1) Enteric nervous system development and Hirschsprung’s disease: advances in genetic and stem cell studies. Nature Reviews Neuroscience 8, 466-479 (June 2007) doi:10.1038/nrn2137
(2) J:175558
(3) http://www.ncbi.nlm.nih.gov/books/NBK10065/ (“caudal to somite 28”)

Thanks

Anna

Discussion

  • Cynthia Smith
    Cynthia Smith
    2014-05-06

    abnormal enteric neural crest cell migration MP_0013006
    abnormal vagal neural crest cell migration MP_0013007
    abnormal sacral neural crest cell migration MP_0013008

     
  • Cynthia Smith
    Cynthia Smith
    2014-05-06

    • status: open --> closed-accepted
    • assigned_to: Cynthia Smith
    • Group: -->