Work at SourceForge, help us to make it a better place! We have an immediate need for a Support Technician in our San Francisco or Denver office.

Close

#1401 glycogen cell

None
closed-accepted
Cynthia Smith
5
2013-10-08
2013-09-24
No

Please consider renaming abnormal glycogen cell morphology [MP:0008958] to “abnormal trophoblast glycogen cell morphology”

NOTE: according to GO, “a glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer”. Modify the current MP definition?

Add the following children terms:

  1. decreased (trophoblast) glycogen cell number:
  2. increased (trophoblast) glycogen cell number

Thanks

Anna

Related

Mammalian Phenotype Requests: #1401

Discussion

  • Chris Mungall
    Chris Mungall
    2013-09-24

    Ideally the MP would use CL here, but CL is insufficient at this time. I
    agree with your proposed changes to MP - CL and GO should be modified to
    reflect this

    CL has:

    [Term]
    id: CL:0000326
    name: glycogen accumulating cell
    namespace: cell
    is_a: CL:0000325 ! stuff accumulating cell

    no definition, no children, no good....

    We need a new child term "trophoblast glycogen cell"
    "A glycogen-accumulating trophoblast cell that arises in the junctional
    zone of the placenta" [PMID:17039549, MP:0008958]

    part_of UBERON:0003972 {source="MP"} ! placenta junctional zone

    Alternatively:

    "A vacuolated glycogen-rich cell that appears in compact cell islets of the
    spongiotrophoblast layer." [GOC:dph, PMID:16269175]
    part_of UBERON:0004021 {source="GO"} ! spongiotrophoblast layer

    GO is better:

    [Term]
    id: GO:0060709
    name: glycogen cell differentiation involved in embryonic placenta
    development
    namespace: biological_process
    def: "The process in which a relatively unspecialized cell acquires
    specialized features of a glycogen cell of the placenta. A glycogen cell is
    a vacuolated glycogen-rich cell that appears in compact cell islets of the
    spongiotrophoblast layer." [GOC:dph, PMID:16269175]
    is_a: GO:0060706 ! cell differentiation involved in embryonic placenta
    development
    relationship: part_of GO:0060712 ! spongiotrophoblast layer development

    I suggest adding a syn to GO "trophoblast glycogen cell differentiation".

    Either way we should all converge on the same definition for the cell type.
    Do you prefer to stick with the one in MP? If so I will percolate the
    changes to CL and GO

    On Tue, Sep 24, 2013 at 1:45 AM, Anna Anagnostopoulos anna_anagnos@users.sf.net wrote:


    [mammalian-phenotype-requests:#1401] glycogen cell

    Status: open
    Labels: new term request
    Created: Tue Sep 24, 2013 08:45 AM UTC by Anna Anagnostopoulos
    Last Updated: Tue Sep 24, 2013 08:45 AM UTC
    Owner: nobody

    Please consider renaming abnormal glycogen cell morphology [MP:0008958] to
    “abnormal trophoblast glycogen cell morphology”

    NOTE: according to GO, “a glycogen cell is a vacuolated glycogen-rich cell
    that appears in compact cell islets of the spongiotrophoblast layer”.
    Modify the current MP definition?

    Add the following children terms:

    1. decreased (trophoblast) glycogen cell number:
    2. increased (trophoblast) glycogen cell number

    Thanks

    Anna


    Sent from sourceforge.net because you indicated interest in <
    https://sourceforge.net/p/obo/mammalian-phenotype-requests/1401/>

    To unsubscribe from further messages, please visit <
    https://sourceforge.net/auth/subscriptions/>

     

    Related

    Mammalian Phenotype Requests: #1401

  • Cynthia Smith
    Cynthia Smith
    2013-09-26

    The textual definition for GO:0060709 specifies that the glycogen cells appear in the "compact cell islets of the spongiotrophoblast layer".. I am not sure this is correct although PMID:16269175 states this. The MP reference PMID:17039549 states that these cells arise in the junctional zone in a separate lineage from the spongiotrophoblasts, but this paper also refers back to that GO reference. PMID:16367805 also supports this view of separate lineages in the junctional zone, not the narrower spongiotrophoblast layer.

    So.. I would prefer to keep the current MP definition, and modify the GO/CL but am keeping an open mind if anyone else has some insight.

     
  • Cynthia Smith
    Cynthia Smith
    2013-09-26

    • status: open --> pending-accepted
    • assigned_to: Cynthia Smith
    • Group: -->
     
  • Cynthia Smith
    Cynthia Smith
    2013-09-26

    Primary term name of MP:0008958 was modified to "abnormal trophoblast glycogen cell morphology".

    New terms added:
    decreased trophoblast glycogen cell number MP:0012109
    increased trophoblast glycogen cell number MP:0012108

     
  • Cynthia Smith
    Cynthia Smith
    2013-10-08

     
  • Cynthia Smith
    Cynthia Smith
    2013-10-08

    I think we have our answer.

    -D

    On 10/1/13 10:43 PM, "Janet Rossant" janet.rossant@sickkids.ca wrote:

    Hi David

    It seems that the glycogen cells do come from the spongiotrophoblast and
    there have been some lineage tracing studies- mostly by Jay Cross or
    Miriam Hemberger's lab. Here are a couple of references;

    Dev Biol. 2011 Mar 15;351(2):277-86.
    Partial loss of Ascl2 function affects all three layers of the mature
    placenta and causes intrauterine growth restriction.
    Oh-McGinnis R, Bogutz AB, Lefebvre L.

    Ablation of Tpbpa-positive trophoblast precursors leads to defects in
    maternal spiral artery remodeling in the mouse placenta.
    Hu D, Cross JC.
    Dev Biol. 2011 Oct 1;358(1):231-9.

    Best wishes

    Janet

    Janet Rossant, PhD
    Senior Scientist and Chief of Research
    Hospital for Sick Children
    Northbridge Chair in Paediatric Research
    University Professor
    Department of Molecular Genetics, University of Toronto

    Peter Gilgan Centre for Research and Learning
    Hospital for Sick Children
    686 Bay Street, 03-9707
    Toronto, ON M5G 0A4
    Canada

    Phone 416-813-7929
    email janet.rossant@sickkids.ca

    Executive assistant: allison.gignac@sickkids.ca
    Phone: 416-813-6577


    From: David Hill [David.Hill@jax.org]
    Sent: Friday, September 27, 2013 9:14 AM
    To: Janet Rossant
    Cc: Cynthia Smith
    Subject: trophoblast glycogen cells?

    Hi Janet,

    It seems like you are my go-to person for questions about cells in the
    early embryo. I hope things are going well with you. We are trying to
    define trophoblast glycogen cells for use in a number of ontologies and
    there seems to be some confusion in the literature regarding their lineage
    and location. Some papers say that they arise from spongiotrophoblast
    cells and some say they don't. We also have some concern about whether the
    junctional zone is considered to be a part of the spongiotrophoblast. Can
    you help shed any light on defining trophoblast glycogen cells or maybe
    point us to a few authors whom you would consider to be authoritative?
    Thanks!

    Best,

    David

     
  • Cynthia Smith
    Cynthia Smith
    2013-10-08

    Based on reply from Janet Rossant, the trophoblast glycogen cell terms have been moved to spongiotrophoblast layer.

     
  • Cynthia Smith
    Cynthia Smith
    2013-10-08

    • status: pending-accepted --> closed-accepted