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#1366 spasticity/hypertonia

Cynthia Smith
Sue Bello

Currently spasticity is a synonym of hypertonia and is located under the abnormal muscle physiology branch. In J:193310 the phenotype "hindlimb spasticity" is reported as a behavioral observation of mice with loss of 2 myelin proteins. Given that there is no assay of the muscle and the problem is in the nervous system, I'm uncomfortable with using the term hypertonia for this phenotype given its current location. I think we should consider separating spasticity from hypertonia and creating a new term under abnormal motor capabilities/coordination/movement for spasticity or else moving hypertonia to the behavior branch similar to the placement of paralysis. The HPO has both terms for hypertonia and (as a child of hypertonia) spasticity both located under the nervous system branch.


  • Cynthia Smith
    Cynthia Smith

    • status: open --> closed-accepted
    • assigned_to: Cynthia Smith
    • Group: -->
  • Cynthia Smith
    Cynthia Smith

    changed primary term name of MP:0004143 to "muscle hypertonia" and synonyms were also amended since the definition clearly referred to muscle

    New terms added:
    spasticity [MP:0012051]
    hypertonicity [MP:0012052]
    limb hypertonia [MP:0012053]