#1211 chronic myelomonocytic leukemia

Cynthia Smith
Sue Bello

Consider adding the term
chronic myelomonocytic leukemia
def from MeSH - A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.
I could find 2 instances of this in MGI (searching for CMML) 1 annotated to leukemia and the other to chronic myelocytic leukemia. Based on the placement in MeSH this term should be a sibling to chronic myelocytic leukemia. In the DO the closest term I can find is myelodysplastic myeloproliferative cancer (definition: A bone marrow cancer that is located_in the bone marrow and results_in the production of too many white blood cells. The cancer possess both dysplastic and proliferative features but are not properly classified as either.) which is the parent term to juvenile myelomonocytic leukemia.


  • Cynthia Smith
    Cynthia Smith

    • status: open --> pending
    • assigned_to: Cynthia Smith
    • Group: -->
  • Cynthia Smith
    Cynthia Smith

    See also ticket #749 request new children of leukemia [MP:0002026] closed to merge to this one.

    See also ticket #266 Leukemia sub-types for lymphocytes closed to merge to this one.

    This is a human disease term; this should be annotated as disease model. Leukemia in mice and human is classified differently according to pathologists. I should further review the existing leukemia terms in the MP for appropriateness.

    Ward JM. Lymphomas and leukemias in mice. Exp Toxicol Pathol. 2006
    Jul;57(5-6):377-81. Epub 2006 May 18. PubMed PMID: 16713211.

    Morse HC 3rd, Anver MR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Jaffe
    ES, Kogan SC, MacLennan IC, Pattengale PK, Ward JM; Hematopathology subcommittee
    of the Mouse Models of Human Cancers Consortium. Bethesda proposals for
    classification of lymphoid neoplasms in mice. Blood. 2002 Jul 1;100(1):246-58.
    PubMed PMID: 12070034.

    Cooments from ticket #266:

    The term leukemia (MP:0002026) has two children terms describing myelocytic leukemiasbut none for lymphocyte-derived leukemia. Unfortunately, there are different classification schemes for these leukemia types… one scheme includes the myeloid leukemia terms presently in the MP and adds the terms Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia
    see : http://en.wikipedia.org/wiki/Leukemia

    (note: this scheme lists the MP term “acute promyelocytic leukemia (MP:0004049) as a subtype of a more general Acute myelogenous leukemia (AML) term)
    The NCI-thesaurus uses a similar (though slightly different) organization

    On the other hand, MESH breaks down terms as Leukemia-> Lymphoid-> B-cell derived> Prolymphocytic or Chronic:


    This more closely resembles the MP layout of lymphoma terms, and the WHO disease vocabulary uses a similar layout.

    Perhaps the conflicting nomenclature is the reason no children terms have been added? I think at least one child term to differentiate lymphoid leukemia from myeloid leukemia would be helpful.

    comments from ticket #749:

    acute lymphoblastic leukemia (ALL)
    chronic lymphocytic leukemia (CLL)

    These are two common types of leukemia, similar to AML & CML, which are children of leukemia.

    Definitions and term names from the HPO:

    id: HP:0006721
    name: Acute lymphatic leukemia
    namespace: medical_genetics
    alt_id: HP:0004803
    alt_id: HP:0005555
    def: "A form of acute leukemia characterized by excess lympoblasts." [HPO:curators]
    synonym: "Acute lymphoblastic leukemia" EXACT []
    synonym: "Acute lymphoid leukemia" EXACT []
    xref: UMLS:C0023449
    xref: UMLS:C1961102
    is_a: HP:0002488 ! Acute leukemia

    id: HP:0005550
    name: Chronic lymphatic leukemia
    namespace: medical_genetics
    alt_id: HP:0006734
    alt_id: HP:0006760
    def: "A chronic lymphocytic/lymphatic/lymphoblastic leukemia (CLL) is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid organs) of morphologically mature but immunologically dysfunctional lymphocytes. A CLL is always a B-cell lymphocytic leukemia as there are no reports of cases of T-cell lymphocytic leukemias." [HPO:curators]
    synonym: "B-cell chronic lymphocytic leukemia" EXACT []
    synonym: "Chronic lymphocytic leukemia" EXACT []
    xref: UMLS:C0023434
    xref: UMLS:C1868683
    is_a: HP:0005558 ! Chronic leukemia

    I was thinking that we should just annotate these to the human disease terms:

    OMIM 151400 Leukemia, Chronic Lymphocytic; CLL
    OMIM 613065 Leukemia, Acute Lymphoblastic; ALL

    BUT, this precludes us from adding an annotation note.

    BUT these terms do not describe a disease in mouse according to accepted pathology, and perhaps should not be used in mouse annotations. See Morse et al "Bethesda proposals for classification of lymphoid hematopoietic neoplasms in mice." Blood 2002; 100(1) p.246-58 PMID:12070034

    I need to look into this further, see J:160846