current:
[Term]
id: CL:0000695
name: Cajal-Retzius cell
namespace: cell
def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912]
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
* Should this be a subtype of CL:0000116 ~ pioneer neuron?
* Also a subtype of bipolar neuron
* Also link to more specific anatomical location
nlx_cell:20081206:
"Neurons of the human embryonic marginal zone which display, as a
salient feature, radial ascending processes that contact the pial
surface, and a horizontal axon plexus located in the deep marginal zone.
These cells were first described by Retzius (Retzius, 1893, 1894) (see
the cell labelled 'Retzius, 1893' in Fig. 1). There is consensus that
homologous elements are present in the non-primate neocortex, where
their morphology is much simpler, as initially described in 1891 by
Cajal (Fig. 2) (Cajal, 1891). nThe definition of these cells has
remained somewhat confusing, in part because Cajal and Retzius studied
different species and different developmental stages, and also because
their original publications have not been generally available. Meyer et
al (1999)prefer to define 'Cajalu2013Retzius cells' loosely, as the
family of Reln-immunoreactive (ir) neurons in the marginal zone, and
reserve the term of pioneer neurons for the early, Reln-negative
preplate derivatives that settle in the MZ and project to sub-cortical
levels. Adapted from Meyer et al. (1999)"
On 2 Dec 2014, at 13:18, Nicole Vasilevsky wrote:
Related
Cell Ontology (CL) requests: #164