NP++ seems to reset Preferences to default after a period of a few weeks and also a recorded macro disappears.
I use NP++ every 3 - 4 days and occasionally not for a week or so. Also I don't update NP++ regularly. But the Preference of default directory has reset a number of times over the last year or so (and three NP++ versions) as well as a simple five key macro (inserting fname and path) assigned to Alt i.
Win7 Home 64bit.
There's an install option, on setup, to do with config files; if it helps. ;-$