I have a monitor with a swivel function and I usually use it rotated by 90 degrees (using NVidia Control Panel). Now, the problem is that on a rotated screen, KeePass Password Safe (2.x) freezes.
I think it's because of the non-standard screen size. I've noticed similar behavior in several .NET framework apps, but not in all of them, so I think the bug is fixable and it's not an MS bug. (The previous version - 1.x - runs fine on a rotated screen).