The University of Michigan (UM) and Global Village Consulting (GVC, Vancouver, BC) have released GVC.SiteMaker as an open source project, under the Educational Community License (SourceForge project name: gvcsitemaker).
This application is tailored for non-technical users who need to create highly customized websites and simple web-databases. It also accomodates extensively distributed management, so that schools, colleges, departments, laboratories and other local units can have full control and responsibility for their materials.
SiteMaker was started at UM, where there are currently over 3500 sites published, serving such diverse purposes as Interactive Teaching Tools, Lab Websites, Public Service, Lecture and Seminar Series Calendars, and many others that are not served by highly stereotyped services (like course management systems). A gallery of UM examples is here: http://sitemaker.umich.edu/sm.gallery
SiteMaker is also being used extensively by the Ann Arbor Public Schools (http://www.aaps.k12.mi.us/) and the Holland Chrsitian Schools (http://www.hollandchristian.org/)