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#9994 NTR: Kap121p transport inhibitory pathway

closed-accepted
8
2013-02-17
2013-02-15
Dianna Fisk
No

As part of spindle assembly checkpoint, a particular pathway of nuclear import (via Kap121) is inhibited. This newly characterized process is described in detail in PMID: 23177738.

To capture the players in this process, we need the following new biological process term (or some variation thereof):

Term: Kap121p transport inhibitory pathway
Synonym: KTIP

Relationships:
GO:0007094 mitotic cell cycle spindle assembly checkpoint
-(part_of) Kap121p transport inhibitory pathway

GO:0042308 negative regulation of protein import into nucleus
-(is_a) Kap121p transport inhibitory pathway

Definition: Any process that decreases the rate, frequency or extent of nuclear transport specifically during spindle assembly checkpoint arrest. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (aka Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p).

Discussion

    • assigned_to: nobody --> paolaroncaglia
     
  • Hi Dianna,

    Based on the definition and the relationships you suggest, I think that the following new term might be more in line with your needs:

    GO:NEW negative regulation of protein import into nucleus during spindle assembly checkpoint
    is_a negative regulation of protein import into nucleus
    part_of mitotic cell cycle spindle assembly checkpoint
    Def: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as part of the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (aka Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p).
    Dbxrefs: PMID:23177738, GOC:dgf
    Synonyms:
    Kap121p transport inhibitory pathway [related],
    KTIP [related],
    negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint [exact],
    negative regulation of protein import into nucleus involved in mitotic cell cycle spindle assembly checkpoint [exact]

    The term name you suggest (Kap121p transport inhibitory [signaling] pathway) would, instead, require a definition more focused on the molecular signals in this pathway, possibly including a start and an end point of the pathway.

    Please let me know if my suggestion for GO:NEW above is ok with you.
    Thanks,
    Paola

     
  • Dianna Fisk
    Dianna Fisk
    2013-02-17

    Sounds good. Thanks Paola!

    -Dianna

     
    • status: open --> closed-accepted
     
  • Hi Dianna, here's your new term:

    id: GO:1901925
    name: negative regulation of protein import into nucleus during spindle assembly checkpoint

    Thanks,
    Paola.