#9906 GAIT complex

Uniprot
closed-accepted
5
2012-12-19
2012-12-18
broechert
No

A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and supresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G.In humans includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.

pmid:15479637, 23071094

Discussion

    • assigned_to: nobody --> paolaroncaglia
     
  • Hi Bernd,

    I've added your new term as GO:0097452 GAIT complex.

    For your reference, the full stanza reads:

    id: GO:0097452
    name: GAIT complex
    namespace: cellular_component
    def: "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP." [GOC:br, PMID:15479637, PMID:23071094]
    synonym: "gamma interferon-activated inhibitor of translation complex" EXACT []
    synonym: "IFN-gamma-activated inhibitor of translation complex" EXACT []
    is_a: GO:0043234 ! protein complex

    Thanks,
    Paola.

     
    • status: open --> closed-accepted