#9756 T-helper follicular cell differentiation

Uniprot
closed-accepted
David Hill
5
2012-11-02
2012-09-28
poux sylvain
No

Category: process

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper follicular cell (Tfh cell), a T-cell subset that provides essential help to B-cells, especially in the germinal center (GC) reactions.

child of GO:0042093 T-helper cell differentiation

synonyms: T follicular helper cell differentiation

PubMed=21572431;

Discussion

    • assigned_to: nobody --> ukemi
     
  • Chris Mungall
    Chris Mungall
    2012-09-29

    suggestion for definition:

    id: CL:0002038
    name: T follicular helper cell
    def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL-6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402]

     
  • David Hill
    David Hill
    2012-11-02

    • status: open --> closed-accepted
     
  • David Hill
    David Hill
    2012-11-02

    GO:0061470

    Chris,
    I didn't add the text of the CL definition to the GO definition. Do you suggest we start doing that as an additional gloss sentence?

    David