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#10006 G1/S transition

closed
nobody
5
2013-02-22
2013-02-22
Pascale Gaudet
No

Hello,

Is there really a difference between
GO:0071779 : G1/S transition checkpoint and
GO:0031575 : mitotic cell cycle G1/S transition checkpoint ?
The 'checkpoint' part of the term suggests that the definition of "GO:0071779 : G1/S transition checkpoint" is right:
A cell cycle checkpoint that blocks entry into S phase of the mitotic cell cycle.

however the definition of "GO:0031575 : mitotic cell cycle G1/S transition checkpoint" seems incorrect to me: "Progression from G1 phase to S phase of the mitotic cell cycle".

Thanks,

Pascale

Discussion

  • Midori Harris
    Midori Harris
    2013-02-22

    GO:0031575 is specific for mitotic, as opposed to meiotic, cell cycles. GO:0071779 is not, and its text definition does not include "of the mitotic cell cycle".

    id: GO:0031575
    name: mitotic cell cycle G1/S transition checkpoint
    namespace: biological_process
    def: "A cell cycle checkpoint that blocks entry into S phase of the mitotic cell cycle." [GOC:mah]
    synonym: "mitotic G1/S checkpoint" EXACT [GOC:vw]
    is_a: GO:0007093 ! mitotic cell cycle checkpoint
    is_a: GO:0071779 ! G1/S transition checkpoint
    is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
    relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle

    id: GO:0071779
    name: G1/S transition checkpoint
    namespace: biological_process
    def: "A cell cycle checkpoint that blocks entry into S phase." [GOC:mah]
    synonym: "G1/S checkpoint" EXACT []
    is_a: GO:0000075 ! cell cycle checkpoint

    (The definition ascribed to GO:0031575 above is actually that of GO:0000082 'G1/S transition of mitotic cell cycle'.)

     
  • Pascale Gaudet
    Pascale Gaudet
    2013-02-22

    Sorry my mistake.

    I was comparing
    GO:0031575 : mitotic cell cycle G1/S transition checkpoint and
    GO:0000082 : G1/S transition of mitotic cell cycle

    Pascale

     
  • Midori Harris
    Midori Harris
    2013-02-22

    OK ... the checkpoint regulates whether the transition takes place.

    It seems GO is missing a term for "G1/S transition" that isn't specific for the mitotic cell cycle ... maybe the cell cycle meeting at the end of this month can take a look.

     
  • Pascale Gaudet
    Pascale Gaudet
    2013-02-22

    My point here is the two terms seem absolutely equivalent.
    The definition of GO:0000082 : G1/S transition of mitotic cell cycle seems wrong (Progression from G1 phase to S phase of the mitotic cell cycle. )

    I propose merging GO:0000082 into GO:0031575.

    Thanks again,

    Pascale

     
  • Midori Harris
    Midori Harris
    2013-02-22

    I disagree. The cell cycle branch does need quite a bit of work, but I don't think it would be correct to merge GO:0000082 and GO:0031575.

    GO:0000082 is a process, and GO:0031575 is another process that regulates the GO:0000082 process.

    I know (from Val) that one of the cell cycle meeting goals is to improve the definitions of the phase transition terms, but it's clear that phase transitions happen, and are regulated.

     
  • Pascale Gaudet
    Pascale Gaudet
    2013-02-22

    • status: open --> closed
     
  • Pascale Gaudet
    Pascale Gaudet
    2013-02-22

    OK, makes sense.

    thanks !

     
  • Valerie Wood
    Valerie Wood
    2013-02-23

    I agree with all of Midori's comments

    It is less clear to me why
    GO:0031575 mitotic cell cycle G1/S transition checkpoint
    is not a child of
    GO:2000045 regulation of G1/S transition of mitotic cell cycle
    and whether these are equivalent, or whther there are multiple parts to GO:2000045 regulation of G1/S transition of mitotic cell cycle

    This is a question still to address.

    Val