#1101 mapping IPR000031 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

InterPro
closed-fixed
nobody
None
5
5 days ago
2013-09-27
Valerie Wood
No

IPR000031

maps to
GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

should it be:

GO:0004638 phosphoribosylaminoimidazole carboxylase activity
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-
D-ribosyl)imidazole + CO(2)

?

Discussion

  • This one is a complicated one. The entry represents the purE enzyme or domain from bacteria and fungi, where it represents a N5-CAIR mutase that produces CAIR. But it also matches a domain of yeast Ade2, which uses a different mechanism to produce CAIR, and in this case represents a AIR carboxylase. So I have removed GO:0034023, as it is definitely not right for all the proteins, but I haven't included GO:000463 because it wouldn't strictly right either.

     
  • Valerie Wood
    Valerie Wood
    6 days ago

    • status: open --> closed-fixed
     
    • Group: UniProt --> InterPro