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#1094 IPR015519 replictive sensence

UniProt
open
nobody
None
5
2013-10-01
2013-09-12
Valerie Wood
No

Doesn't feel right as a mapping for ATM checkpoint kinase for yeast
O74630
Val

Discussion

  • I agree, it sounds like a term that should be applied to multicellular organisms. Still, there is no taxon restrictions for this term. Nevertheless I have removed it.

     
  • Hsin-Yu Chang
    Hsin-Yu Chang
    2013-10-01

    I think it is ok to give this term to yeast Tel1. From papers (PMID:23672410, PMID:
    22033189), you can find the description of yeast Tel1 involved in replicative senescence. I agreed that the definition of senescence might be different between mammals and yeasts. However, both ATM and Tel1 both play an important role in telomere maintenance, and this links them to replicative senescence in humans and yeasts (PMID:15610769, PMID:23672410).

    p.s. I used to work on telomere capping in budding yeast, therefore, I am sure about the term "replicative senescence" is applicable in budding yeast.