After a while, the mouse stops working on the virtual machine. If this can help, I use Virtual Box and a wireless USB mouse.
Does the mouse still work in the host os? About how long is a while, 5min, 3 hours of random use, ...? Which mouse driver are you using and its version (e.g. cutemouse from 1.1 distribution) ? Thank you.
It works in the host, the time it takes seems to change, and I use the default driver.