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Im using the german version of windows xp and when DrPython tries to execute "internet explorer" e.g. to display the help itll try to use hardcoded "c:\program files\..." which will of course fail on non-english versions (different name for this directory).
Dont know if its a DrPython or wxPython issue though.
Try going into Preferences, under "Documentation".
Change the browser to the path to the executable you want to use.
That should get it.