Would you consider the following as valid smiles?
This example is from SmilesGeneratorTest.testCisTransDecalin(), it is trying to represent is the cis/trans ring configuration but is this possible in the specification? In my mind it should simply the clockwise/anti-clockwise chiral atoms?
From the ambit depictions the toolkits which handle chiral smiles input don't seem like the cis/trans configuration of the ring. I've checked the Daylight and OpenSMILES manuals but can't find any mention of cis/trans ring configurations.