| 1 | <?xml version="1.0" encoding="UTF-8"?> |
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| 2 | |
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| 3 | <neuroml xmlns="http://www.neuroml.org/schema/neuroml2" |
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| 4 | xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" |
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| 5 | xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 ../Schemas/NeuroML2/NeuroML_v2alpha.xsd" |
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| 6 | id="NML2_FullNeuroML"> |
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| 7 | |
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| 8 | |
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| 9 | <!-- Example containing a range of different elements from NeuroML 2 --> |
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| 10 | |
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| 11 | |
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| 12 | |
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| 13 | <!-- Bioelectrical properties of different media --> |
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| 14 | |
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| 15 | <!-- used for reactions outside all cells --> |
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| 16 | <extracellularProperties id="extracellular" temperature="32degC"> <!-- Perhaps temp could be an attribute here? --> |
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| 17 | |
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| 18 | <!-- see FullNeuroML_SBML.xml for example with SBML interaction --> |
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| 19 | |
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| 20 | </extracellularProperties> |
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| 21 | |
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| 22 | |
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| 23 | |
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| 24 | |
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| 25 | <!--++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++--> |
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| 26 | <!-- Strucure of cell neurites --> |
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| 27 | |
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| 28 | <morphology id="NeuroMorpho_PyrCell123"> <!-- see FullCell.xml for more details --> |
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| 29 | |
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| 30 | <segment id ="0" name="Soma"> |
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| 31 | <!-- no parent => root segment --> |
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| 32 | <proximal x="0" y="0" z="0" diameter="10"/> |
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| 33 | <distal x="10" y="0" z="0" diameter="10"/> |
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| 34 | </segment> |
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| 35 | |
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| 36 | <!-- more needed --> |
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| 37 | |
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| 38 | </morphology> |
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| 39 | |
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| 40 | |
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| 41 | |
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| 42 | <!--++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++--> |
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| 43 | <!-- Ion channel specification --> |
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| 44 | |
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| 45 | <ionChannel id="HH_Na" type="ionChannelHH" conductance="10pS" species="na"> <!-- see SimpleIonChannel.xml for more details --> |
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| 46 | |
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| 47 | <!-- more needed --> |
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| 48 | |
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| 49 | </ionChannel> |
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| 50 | |
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| 51 | |
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| 52 | |
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| 53 | |
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| 54 | |
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| 55 | <!--++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++--> |
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| 56 | <!-- Synaptic mechanism specification --> |
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| 57 | |
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| 58 | <expTwoSynapse id="AMPA" gbase="0.5nS" erev="0mV" tauRise="1ms" tauDecay="2ms" > |
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| 59 | |
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| 60 | |
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| 61 | </expTwoSynapse> |
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| 62 | |
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| 63 | |
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| 64 | |
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| 65 | <!--++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++--> |
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| 66 | <!-- Biophysical properties of cell incl membrane, e.g. conductance densities, specific capacitance, etc. --> |
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| 67 | |
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| 68 | <biophysicalProperties id="PyrCellChanDist"> |
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| 69 | |
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| 70 | <membraneProperties> |
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| 71 | |
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| 72 | <!-- see FullCell.xml for more details on membraneProperties--> |
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| 73 | |
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| 74 | <channelDensity id="naChans" |
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| 75 | ionChannel="HH_Na" |
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| 76 | segmentGroup="soma_group" |
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| 77 | condDensity="120.0 mS_per_cm2" |
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| 78 | erev="50mV"/> <!-- Temporarily specifying erev in the channelDensity element--> |
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| 79 | |
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| 80 | <!-- Ions present inside the cell. Note: a fixed reversal potential is specified here |
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| 81 | <reversalPotential species="na" value="50mV"/> |
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| 82 | <reversalPotential species="k" value="-77mV"/>--> |
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| 83 | |
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| 84 | <!-- more needed --> |
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| 85 | </membraneProperties> |
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| 86 | |
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| 87 | <intracellularProperties> <!-- used for bioelectrical properties inside a cell --> |
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| 88 | |
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| 89 | <species id="ca"> |
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| 90 | <fixedConcentration concentration="0.0001 mM"/> |
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| 91 | </species> |
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| 92 | |
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| 93 | |
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| 94 | <resistivity value="0.1 kohm_cm"/> <!-- Used for specific axial resistance --> |
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| 95 | |
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| 96 | <!-- REMOVED UNTIL WE CHECK HOW THE USAGE OF LEMS IMPACTS THIS... |
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| 97 | <biochemistry reactionScheme="InternalCaDynamics"/> Ref to earlier pathway --> |
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| 98 | |
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| 99 | </intracellularProperties> |
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| 100 | |
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| 101 | </biophysicalProperties> |
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| 102 | |
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| 103 | |
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| 104 | |
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| 105 | <!--++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++--> |
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| 106 | <!-- A cell is created by referencing its morphology and membrane/internal properties --> |
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| 107 | |
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| 108 | <cell id="PyrCell" |
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| 109 | morphology="NeuroMorpho_PyrCell123" |
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| 110 | biophysicalProperties="PyrCellChanDist"/> <!-- see FullCell.xml for a full cell example --> |
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| 111 | |
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| 112 | |
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| 113 | |
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| 114 | <!--++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++--> |
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| 115 | <!-- A network of the cells is created --> |
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| 116 | |
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| 117 | <network id="PyrCellNet"> |
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| 118 | |
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| 119 | <!-- see NestedNetwork.xml for a more detailed network containing these elements --> |
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| 120 | |
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| 121 | <population id="Population1" |
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| 122 | cell="PyrCell" |
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| 123 | extracellularProperties="extracellular" |
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| 124 | size="9"> <!-- Population is "placed" in medium --> |
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| 125 | <!-- |
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| 126 | <layout space="Grid_2D"> |
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| 127 | <grid xSize="3" ySize="3"/> |
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| 128 | </layout>--> |
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| 129 | |
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| 130 | </population> |
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| 131 | |
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| 132 | <!--<cellSet id="AllExcitatoryCells" select="Population1"> |
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| 133 | ... |
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| 134 | </cellSet>--> |
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| 135 | |
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| 136 | <projection id="Proj1"> |
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| 137 | <!-- ... --> |
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| 138 | </projection> |
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| 139 | |
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| 140 | </network> |
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| 141 | |
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| 142 | |
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| 143 | </neuroml> |
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